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Brandon Twyford
Brandon Twyford
Brandon Twyford is the Senior Editor for GI Oncology Now
Articles by Brandon Twyford
KEYFORM-007 Results: Co-Formulated Favezelimab and Pembrolizumab in Metastatic Colorectal Cancer
Brandon Twyford
Colorectal Cancer
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March 19, 2025
The study showed that favezelimab/pembrolizumab did not demonstrate a survival benefit over SOC.
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Promising Results for Triplet Blockade Therapy in Unresectable Hepatocellular Carcinoma
Brandon Twyford
Liver Cancer
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March 19, 2025
The study reinforces the potential of triplet blockade with casdozo, atezo, and bev as a viable approach for managing uHCC.
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CtDNA Shows Promise for Detecting Molecular Residual Disease in Stage II/III Colorectal Cancer: BESPOKE CRC Final Analysis
Brandon Twyford
Colorectal Cancer
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March 19, 2025
The study shows the prognostic value of ctDNA in detecting MRD in patients with stage II/III CRC.
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ACCELERATE Trial: Evaluating Adjuvant Therapy in Resected Gallbladder Cancer
Brandon Twyford
Liver Cancer
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March 19, 2025
Trial results show no significant benefit of adding chemoradiation to adjuvant chemotherapy in resected gallbladder cancer.
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Clinical Outcomes and Hepatobiliary Toxicities Associated With Liver SBRT: A Retrospective Study
Brandon Twyford
Liver Cancer
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March 19, 2025
SBRT shows promise for liver tumor control, but hepatobiliary toxicity remains a concern.
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CHALLENGE Trial Final Results: Atezolizumab Plus Bevacizumab in Advanced HCC With Child-Pugh Class B Cirrhosis
Brandon Twyford
Liver Cancer
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March 19, 2025
Atezolizumab plus bevacizumab shows promising efficacy and tolerability for advanced HCC with Child-Pugh B cirrhosis.
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Hepatocellular Carcinoma Mortality Rates Rising in the US, Driven by Alcohol and Metabolic Liver Diseases
Brandon Twyford
Liver Cancer
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March 19, 2025
Rising HCC mortality rates in the US highlight stark disparities across age, sex, race, and liver disease etiologies.
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CHMP Recommends Tislelizumab for First-Line Therapy in Advanced Gastric and Esophageal Cancers
Brandon Twyford
Gastric Cancer
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March 19, 2025
Tislelizumab shows significant survival benefits in first-line treatment for gastric and esophageal cancers.
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POD1UM-303: Retifanlimab Plus Chemotherapy Improves PFS in Metastatic Squamous Cell Carcinoma of the Anal Canal
Brandon Twyford
GI Cancer
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March 19, 2025
Retifanlimab plus chemotherapy showed improved PFS and response rates in locally recurrent or metastatic SCAC.
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RAMTAS: Ramucirumab Plus TAS102 Shows Survival Benefit in Specific Subgroups of Metastatic Colorectal Cancer
Brandon Twyford
Colorectal Cancer
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March 19, 2025
The RAMTAS trial explored ramucirumab plus TAS102, benefiting select chemotherapy-refractory mCRC patients.
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LEAP-012: Lenvatinib Plus Pembrolizumab Improves PFS in Intermediate-Stage HCC
Brandon Twyford
GI Cancer
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March 19, 2025
The LEAP-012 study showed improved progression-free survival with lenvatinib, pembrolizumab, and TACE in HCC.
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BREAKWATER Trial: Encorafenib Plus Cetuximab With FOLFIRI Shows Strong Efficacy in BRAF V600E-mutant mCRC
Brandon Twyford
Colorectal Cancer
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March 19, 2025
Combining encorafenib and cetuximab with FOLFIRI chemotherapy showed strong antitumor activity in BRAF V600E-mutant mCRC.
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T-DXd with Fluoropyrimidine and Pembrolizumab Shows Strong Antitumor Activity in Advanced HER2+ Gastric, Esophageal Cancers
Brandon Twyford
Gastric Cancer
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March 19, 2025
Trastuzumab deruxtecan, pembrolizumab, and chemotherapy shows benefits in advanced or metastatic esophageal, gastric, or GEJA
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POLAR: Pembrolizumab, Olaparib Extends Survival for Select Patients With Metastatic Pancreatic Cancer
Brandon Twyford
Pancreatic Cancer
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March 19, 2025
Results showed 64% of patients with HRD mPC were progression-free at 6 months with pembrolizumab and olaparib.
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Liquid Biopsy-Guided Cetuximab Rechallenge Demonstrates Improved Response, Disease Control Rates for mCRC
Brandon Twyford
Colorectal Cancer
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March 19, 2025
Cetuximab rechallenge guided by liquid biopsy improved response and disease control rates in RAS wild-type mCRC.
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FDA Grants Accelerated Approval for Adagrasib Plus Cetuximab in KRAS G12C-Mutated Colorectal Cancer
Brandon Twyford
Colorectal Cancer
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March 19, 2025
The US FDA recently granted approval for the combination of adagrasib and cetuximab for mCRC with KRAS G12C mutation.
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Novel Peptide Binder to Glypican-3 Shows High Specificity as a Theranostic Agent for Hepatocellular Carcinoma
Brandon Twyford
Liver Cancer
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June 11, 2024
[68Ga]Ga-RYZ-GPC3 shows high specificity in detecting hepatocellular carcinoma, outperforming conventional imaging.
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Nivolumab Plus Ipilimumab Shows Promise as First-Line Treatment for Advanced Liver Cancer: CheckMate 9DW
Brandon Twyford
Liver Cancer
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March 19, 2025
CheckMate 9DW trial: Nivolumab plus ipilimumab improves overall survival in unresectable hepatocellular carcinoma
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PASS-01 Trial: Modified FOLFIRINOX Versus Gemcitabine/Nab-Paclitaxel for Advanced PDAC
Brandon Twyford
Pancreatic Cancer
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March 19, 2025
The trial compared mFOLFIRINOX vs gemcitabine/nab-paclitaxel in advanced PDAC.
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Phase 3 IKF-575/RENAISSANCE Trial: Surgery After FLOT in Limited Metastatic Gastric Cancer
Brandon Twyford
Gastric Cancer
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March 19, 2025
Phase 3 IKF-575/RENAISSANCE trial shows surgery after FLOT may benefit RPLN-only metastatic gastric cancer patients.
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